Essays on Sickle-Cell Disease

Introduction

Sickle Cell Anemia or Sickle Cell Disease is an inherited blood ailment. Those suffering from Sickle Cell Disease have abnormal S/ sickle hemoglobin in the red blood cells. Hemoglobin is the protein in the blood that aids in carrying oxygen throughout the body. The ailment takes its appellation from the shape of the red blood cells of a person affected by Sickle Cell Disease, which have the shape of a sickle. They are stiff and adhesive rather than a disk like normal cells. The misshapen cells tend to get trapped in the small blood vessels hindering the movement of ...

Coursename Sickle-cell anemia is a genetic blood disorder, which affects the red blood cells. It was first described in the medical literature in 1846. In 1910, Ernest Irons became first to write about the pathologically altered red blood cells of the patient with sickle-cell anemia (Serjeant 425-429). It is caused by the mutation of the gene encoding the synthesis of the hemoglobin. As a result, the hemoglobin of the affected people is defective (hemoglobin S). Glutamic acid in it is substituted with valine in the sixth position of the β-chain. This change greatly reduces the solubility of hemoglobin in ...

Abstract

Sickle cell anemia is a hereditary disorder in which the red blood cells, which function as the oxygen carriers throughout the body, develop in an abnormal manner. The red blood cells are normally disk-shaped and very flexible but in sickle cell patients the cells often become very rigid and crescent shaped. This abnormality in the shape and functionality of the red blood cells hinder the normal flow of blood in the body. The red blood cells are therefore rendered unable to move freely through the blood tissues and through organs that result in the failure of certain important organs ...

Sickle cell anemia is the most widely inherited genetic disorder in the United States. Folic acids are one important nutrient that helps increase and produce some red blood cells in the bone marrow. This paper investigates how folic acid has used a supplement for pregnant women. Sickle cell anemia can be genetically passed to the baby from a mother who has it or who is a carrier. Symptoms of the disease include headaches, irritability, fatigue, dizziness, diarrhea, cold feeling, difficulty when breathing, difficulty concentrating and pale skin ( Lindenbaum, John, and Klipstein ,16 ). Malnutrition in pregnant women is the commonest ...

Introduction

King Tutankhamun also known as King Tut or Tutankhamen was an Egyptian pharaoh who ruled between the period of 1336 and 1327 BC. He is believed to the 12th ruler of the 18th Dynasty of Egyptian history (Carter and Romer 2008). His precious mummy discovered in 1922, in the Valley of Kings by Howard Carter and George Herbert first brought king Tutankhamun to light.. It is the discovery of Tutankhamun’s mummy that first made Tutankhamun and his lineage a subject of public interest worldwide. A lot of facts have been uncovered about him ever since, and all these facts ...

Relevance of nursing research problem, addressed in SRR

The research review, developed by Lanzkron, Wilson, Beach, Haywood, Park and Segal (2008), is dedicated to studying published literature on the efficacy, effectiveness and toxicity of hydroxyurea, when used in adults with sickle cell disease. Sickle stem disease is a dangerous condition that tends to decrease life expectancy by 25-30 years and cause high morbidity level, while hydroxyurea remains the only approved disease-modifying therapy (Lanzkron et al., 2008, p.939). Taking into account severity of the disease and the fact that the drug under study is the only available non-supportive therapy, studying its efficiency, efficacy and toxicity is highly relevant for ...

Sickle cell is a hereditary disease that that has no cure. The disease cause blood disorders and is the most common form of sickle cell disease. The disease affects the hemoglobin in the red blood cell since the disease cause mutation of hemoglobin (Genetics Home Reference 2012). Thus, an individual with the disease produce both normal and abnormal hemoglobin. The sickly abnormal cells block the blood flow. Hence, as the result of blocked blood flow in the body that the cause inflexibility of red blood cells can raise the risk for infection that are life threatening chronic diseases that can ...

Brittani Scott

Introduction Sickle-cell disease is an illness that is multisystem, linked to episodes of progressive damage of organ and acute illness, and is among the most common dangerous monogenic disorders in the world (Weatherall, Hofman, Rodgers, Ruffin, & Hrynkow, 2005). The sickle-shape erythrocytes were initially described in the year 1910 by Herrick (Herrick, 1910) and understanding has slowly increased from that time. Together with his colleagues, Pauling (1949) keyed out electrophoretic abnormalities in sickle HbS and made up the word molecular disease in the year 1949. The genetics, as well as biophysics of hemoglobin behind the disease, have been widely ...

Question one

Microscope (Polyethylene reservoirs) ( Short rectangular capillary) plati-num wire electrode This is because the red blood cell would be clearly observed using rectangular capillary. This column would enable observation of the movement of particles hence a thorough study of the mobility of the components of the red blood cells would be taken into account. Because a person is able to evaluate or rather observed the change of red blood in the capillary column is reason enough to diagnose Martin b the disease.

Question two

HbS S molecules would be likely to clump together because of the presence of the sickle cell anemia. ...

Introduction

Sally Thomas is a twenty three years old mother and is comprehensively covered in this clinical scenario. The scenario covers aspects of her family history which are of essence to any medical decisions associated with any clinical procedure. The aspect of her past pregnancies will be comprehensively articulated in the case study. Her medical history will be analyzed and clinical solutions proposed for her problems. It is pertinent to note that the scenario will be comprehensive and will articulate each stage of the pregnancy. The scenario will be broken down into multiple sub section which includes the ante partum, fetal ...

Introduction

An article published by the Cochrane Collaboration and posted in the Cochrane Library in 2012 caught my attention. The article stated that no quasi-randomized or randomized clinical trials of gene therapy for sickle cell disease have been documented. The article further stated that no conclusions and recommendations are attributed to the application of gene therapy on sickle cell disease (Olowoyeye & Okwundu, 2013). This statement inspired me to evaluate the current developments in gene therapy that targets sickle cell disease. Sickle cell disease is one of the oldest genetic disorders and yet few attempts have been made to develop gene ...

Child and adolescent health issues require extra concentration due to the fact that an early disease can lead to an improper growth which may impact the entire life of a person and therefore it is important to ensure that childhood and adolescence diseases are looked after with extreme care in order to improve the quality of life and the growth of the patients. Sickle cell anemia is one of the widely studied subjects today, considering that it can cause acute chronic conditions which include severe pain and organ dysfunctional ties and has a high fatality rate. This disease is also known ...

Sickle cell anemia is an inherited disorder of the blood where the red blood cells form an abnormal crescent shape. The Red blood cells deliver oxygen from the lungs to the body tissues are generally flexible and round, facilitating them to move easily through the blood vessels. Nevertheless, in individuals with sickle cell anemia, the texture and shape of the red blood cells can vary. They turn out to be sticky, hard and take the shape of a disc. The cells die prematurely, resulting to a deficiency of red blood cells (David, 2011). Sickle cell anemia is passed through families ...

Abstract

Incredible advancements in nursing service intervention have forged immense reformation of techniques in treating numerous diseases. The overall aim is to improve outcomes and promote efficient nursing care. As such, the American Nurse Credential Center (2008) has developed a model which provides the framework for future nursing practice. Also, it is expected to serve as a guideline for organizations wishing to achieve recognition in the Magnet Hospital program (American Nurse Credential Center, 2008). This exposition encompassing a literature review is a sample of both the components of this model as well as forces linked to its execution process within the context of magnetism ( ...