Essays on Signaling

(Author’s affiliation) Diabetes is a polygenic disease characterized by significantly higher levels of glucose in the blood. In this disorder, metabolic disorders lead to persistent thirst (polydipsia) and excessive level of urination (polyuria). Diabetes is caused by insulin-related disturbances in the body. In healthy human beings, pancreatic β cells have insulin that is found as a hexamer having three insulin dimers attached together by two central zinc ions. The insulin monomer has a 21-residue A chain as well as a 30-residue B chain. These chains are cross-linked by two disulfide bridges, i.e. CysA20-CysB19 and CysA7-CysB7. There is also a ...

Introduction

Atherosclerotic cardiovascular disease (CVD) involves peripheral circulation, the brain, and the heart. The disease is a primary health issue in many countries around the world (Sawhney, et al., 2012). CVD develops through complex processes involving novel risk markers and common risk factors. Decades of research have demonstrated that a sibling’s or parent’s family history is linked to the development of atherosclerotic CVD (Gupta et al., 2013; Nelson, 2013; Imes and Lewis, 2014), which manifests as peripheral arterial disorder, stroke, and coronary heart disorder (CHD). Various Mendelian disorders have also been shown to contribute to atherosclerotic CVD. Although ...

1. Biot’s respiration named after Camille Biot is an abnormal ataxic breathing pattern, where rapid series of shallow respiration are followed by a period of apnea. In order to known how AMP kinase, knock down leads to Biot respiration in mice; it is necessary to known how AMP kinase affects respiratory rate. AMP kinase is a metabolic sensor and is activated in response to stretching of the lung alveolar cells and other stressors. During respiration, the lung goes through cycles of expansion and contraction (Budinger et al., 2008). When the alveolar cells stretch during expansion, the 5′ AMP-activated ...

In this paper, the analysis of “Blood flow reprograms lymphatic vessels to blood vessels” is discussed and the highlighted part is supported with the help of evidence and other research studies. There are some common congenital diseases are discussed in this article indicating how genetic lineage tracing become a reason for a change in vessels. It is analyzed that replacement by blood endothelial cells is not a solution, and lymphatic endothelial cell reprogramming is supported with the help of researches and experiments (Chen, et al., 2012). According to the past researches, the vascular defect may result in a stroke ...

Abstract

Executive Coaching is a relatively new Human Resource Development process aimed at helping a client to reach his full potential in an organization. This process consists of preparing him to execute the responsibilities of a leader, a decision maker, change facilitator as well as guiding him to deal with the stress, maintain a work life balance and develop an ethical approach towards his work. Although the profession of an executive coach does not need a specific academic degree or practice license like the well established profession of a Psychologist, there are some distinct similarities between the two which have ...

Internal Analysis of Encana

Internal Analysis of Encana

Introduction

The oil and gas industry in North America is currently experiencing challenges and transition stage. The increasing need for the environment-friendly and sustainable forms of energy is affecting the industry negatively as more governments and companies are encouraged to use energy with no or low carbon emission. More companies are now developing solar and wind energy and create vehicles that can rely on electricity rather than oil. Such growing trend in the energy sector resulted to lower demand of oil and gas particularly in the North America. Many oil and gas producing countries and companies ...

A proposal in partial fulfillment of the requirements for the degree of

Introduction Wheat (Triticum sp.), an extensively adapted crop, is one of the primitive and primary staple food crops in the world. Wheat is cultivated from temperate; dry to irrigated or rain-fed areas, to warm, humid or cold conditions. Such a high adaptability is attributed to its intricate genome (Acevedo et al., 2002). Wheat cultivation covers more land area compared to other commercial crops and endures to be an essential food grain for humans (Curtis, 2002). Estimations reveal that by 2050, the population of the world will reach 9.1 billion (34 percent greater than today); correspondingly, the food requirement and ...

Introduction

The large production of bisphenol A (BPA) in the world has been documented because of the increased usage of the same in various industries. The most critical industries that have been using this BPA include those manufacturing containers for foods and beverages, cigarette filters, thermal receipts as well as paper currency. With such a huge provision, it is critical that the basis of such developments only emanates from making the right choices over its uses because its production to a total of 2.7 million tons could be disastrous to the body. The main reasoning here is that the chemical ...

Vid30 complex participation in the degradation of CDC25 in yeast and their role in Ras/ cAMP/ PKA pathway

Background: Unicellular organisms such as Saccharomyces cerevisiae in its total life cycle is exposed to diverse and changing nutrient conditions. Thus, in order to survive and achieve a competitive advantage, it has adapted itself such that it not only uses the wide range of available nutrient sources but also the sources that are nutrient rich. It mainly uses fructose and glucose by rapidly fermenting to alcohol. In response to these nutrient conditions, the intracellular trafficking transcription and turnover of protein from nutrient transporters (e.g. Hxts) get regulated. Therefore, when the availability of the glucose increases, the expression of low- ...

Biomolecules serve different functions in a cell. The three major classes of biomolecules in the cell are: proteins, nuclei acids and carbohydrates. These molecular structures serve nearly similar functions in most organisms. Though the function of protein in forming cell architecture, signaling and communication is well known, little is known about the role of carbohydrate in communication. Nevertheless, it goes un-denying that carbohydrates are indispensable for cellular communication and signaling, just like proteins and nucleic acids. The paper titled, Carbohydrates in Cell Recognition, by the authors Nathan Sharon and Halina Lis, is a good review that elucidates the significance ...

In Tissenbaum and Guarente's research study, they concluded that increasing the dosage of a SIR2 gene is associated with extended lifespan of roundworms, Caenorhabditis elegans (Tissenbaum & Guarente 228). To easily understand their research study, let us discuss a little background abound longevity of C. elegans. In 1997, a research study headed by Kimura, Tissenbaum, Liu and Ruvkun found the gene that potentially regulates the longevity and diapause in Caenorhabditis elegans. In C. elegans, their life cycle after the initial larval stage can proceed to two different stages: either the reproductive stage, or the dauer diapause stage (Hu). In their ...

<<Author>> <<Date>> According to Xu et al. (2012), multiple tissues and organs in our body have this signaling system with AMPK and the balance in energy is accomplished by these sensors. The regulation done by this pathway is very important and any deficiency can lead to disorders like type 2 diabetes, obesity and other syndromes. Whenever nutrient insufficiency occurs the activation of AMPK takes place; which signals feeding. These are controlled in the hypothalamus region with the use of glucose, leptin and insulin (Akabas et al., 2012). AMPK and mTOR play a very ...

Voice over IP

Abstract Organisations and business alike are embracing the use and application of various forms of information technology in their business processes and operations in equal measure. There is a myriad of benefits associated with the use and application of various forms of information technology in business operations and processes. Computer networking has facilitated the advancements currently witnessed in information technology (Jahanirad, AL-Nabhani and Rafidah 4954). While the use and application of information technology have its benefits, it presents various disadvantages as well. Voice over IP is one form of information technology that has been utilised by numerous businesses and ...

Price: 438.31 GBP Date: 4 May 2016

Company profile: Aviva Plc provides insurance, savings, and investment products to over 31 million customers around the world (Aviva, 2016). Aviva is a composite insurance that combines life insurance, general insurance, and asset management (Aviva, 2016). Aviva operates worldwide with its headquarters in London United Kingdom (Yahoo! Finance, 2016).

One-year Price chart:

Figure 1: One-Year Aviva Price Chart

Source: Bloomberg

Price performance: Valuation (by DDM and by comparables):

Analysts’ recommendation:

Introduction 3 Price performance and news analysis 3 News 4 Valuation 5 Multi-stage DDM 5 SML analysis 6 Discussion of pros and cons of the methods used for the above valuation 7 Conclusion 10

Appendix 13

Exhbit1: ...

Gene Expression and Signaling Class

Short Answer Different Phenotype in PTEN Mutations While PTEN is either mutated or lost in both spontaneous and heritable cancers, the p110 alpha is frequently mutated in major forms of cancer such as breast cancer, endometrial, colorectal, ovarian, and prostate cancers with a greater prevalence of breast cancers (Nagata et al., 2004). Besides, the monoallelic loss of PTEN mostly contributes to the growth of tumor in the context of other somatic mutations in which case the count of PTEN proteins correlates with the severity of cancer, an indication that PTEN is haploinsufficient in functionality. Additionally, while the gene encodes ...

Drawing from the seminar presentation, I have gathered that the mechanistic target of rapamycin (mTOR) signals various pathway functions and regulates critical functions in the placenta such as mitochondrial respiration and nutrient transport. Placental amino acid transporter activities are significantly decreased in intrauterine growth restriction (IUGR) with recent experimental research evidence suggesting that the changes directly contribute to restricted fetal growth (Jansson, 2016). In this case, placental nutrient sensing is seen to have a pivotal role in the modulation on resource allocation between the mother and fetus thus affecting overall fetal growth, preventing overgrowth of the fetus and ensuring ...

Introduction

In financial management, the finance managers primarily make several kinds of decisions including investment decisions, financing decisions, routine decisions and dividend decisions. For this case, the paper focusses on dividend decisions. The paper shall evaluate the theoretical framework and empirical evidence that examines the relationship between the firm’s dividend policy and its market share price. Quantitative business analytics refers to application of mathematics and statistics to solve business problem. From the definition, it means that one to define the business problem to solve first then apply the relevant techniques. In this case, the paper hopes to understand the ...

Abstract

This paper discusses how exercise stimulates the release of growth hormone. Older people tend to have lower levels of the hormone. As a result, mechanisms have been formulated to help deal with the deficiency which includes inducing the growth hormone into the individual’s body. This, therefore, leads to the discussion of the exact mechanism through which the growth hormone facilitates exercise, maintains growth and repair of worn out muscles or even reverses the aging process among the aged. Also, the functions of IGF-I binding proteins during exercise and its importance in aiding the release of the GH is ...

While much has been hypothesized regarding paranoia, it is of the essence to note that it mainly connotes to a condition whereby an individual develops a feeling of suspicion towards others. Precisely, persons suffering from paranoia tend to harbor the thoughts that other people are against them. In fact, paranoid individuals tend to think that other people intend to harm them (Sarkar et al., 2012). As a result, paranoia makes people develop certain behaviors aligned to being highly conscious. A reflection on the lives of every individual depicts the fact that at one time in life, an individual develops ...

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Abstract Fibromyalgia is a muscular disorder characterized by pain, sleep disturbance, and fatigue. In case of pain, certain “tender points” can develop in the body, which are highly sensitive to any kind of pressure. This disorder is most commonly found in women as compared to men. Patients of rheumatoid arthritis and autoimmune disorders have more chances of developing the disorder. It is often difficult to diagnose as the symptoms are vague and generalized. Although, exact cause of the disorder is not clear, increased sensitivity to the signaling of central nervous system, genetic factors, and psychiatric aspects ...

{Author Name [first-name middle-name-initials last-name]} {Institution Affiliation [name of Author’s institute]} A cell is a form of the miniature factory that encloses a distinct chemical system that is involved in structural maintenance, homeostasis, energy generation and reproduction. Every organism is made of these structural living units. The cell divides and produces more cells and assists in the growth of the organism. There are two types of cells, eukaryotic and prokaryotic. Eukaryotic cells are characterised by a membrane-bound nucleus enclosing the genetic material. The Eukaryotic cells can be divided into three main parts, plasma membrane, cytoplasm, and nucleus (Cooper & ...

How VOIP Works.

Chris Woodford in his article explains the workings of VOIP (Voice Over Internet Protocol) through the analysis of Skype (a popular internet telephony software). Chris maintains that telephone technology has remained almost the same since the 19th century and in the 21st century one must be using the better available technologies of the internet. The technological advancements have not only made it possible to communicate with other people in a fast and efficient manner but also reduced the cost for the same. In the article, Chris describes the functioning of VOIP, detailing Call Signaling, Call transmission, interfacing with the ...

Abstract

Cancer of the lungs is among the leading causes of cancer in the world. It has two forms; small cell lung cancer (SCLC), and non-small-cell lung cancer (NSCLC). NSCLC constitutes about 85% of cases of lung cancer. Epidermal growth factor receptor (EGFR) and its mutations are found to have an important role in this cancer. Therefore, EGFR tyrosine kinase inhibitors (TKIs) can work effectively against NSCLC. Gefitinib, which is a first generation TKI, and afatinib, which is a second-generation TKI, are effective as a first-line therapy for advanced NSCLC. Erlotinib is effective as a second-line therapy for advanced NSCLC. ...

Introduction

Following the drops witnessed with the overall prices within the oil industry, it has been recorded that majority of the dependent industries have been reported devaluation in both their asset bases and their stock items. This is the suggestion of the Bushee and Miller (2013) on presenting the oil industry as one industry that is heavily depended upon by a majority of the sectors within commerce and industrialization. Suggestively, this is true based on the use of oil within the manufacturing sector, the energy and allied sectors, the transport sectors, and production industries. With this highlighted, the effect of ...

Introduction

The total number of patients with cancer keeps soaring globally with around 14 million cases diagnosed by 2014. Each year, about 8 million people die of cancer-related illnesses globally. There are quite some remedies that have been proposed to mitigate in the cancer menace. This study is focused on cancer treatment by curcumin through tyrosine kinase inhibition. Curcumin is the primary coloring agent found in turmeric, a tuber of the herb Curcuma longa Lin. It has widespread use as a flavoring agent (Aggarwal and Bokyung 87). It is also well known for its medicinal value commonly used to suppress ...