Skin cancer or metastatic melanoma is one of the most aggressive types of cancer (Chin, Garraway, and Fisher, 2006). Understanding the physical or phenotypic alterations that occur in relation to skin cancer requires getting acquainted with its pathophysiology. Furthermore, learning the pathophysiology of metastatic melanoma can lead us to a better understanding of what may be most effective in curing the disease. Metastatic melanoma, causing approximately 13,000 deaths annually with a median overall survival (OS) period of 8 to 18 months, is considered as one of the most aggressive and prevalent types of cancer (Finn, Markovic, and Joseph, 2012). ...
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What is the evidence that convinces you Cancer Stem Cells are a subpopulation of tumour cells with distinct tumour‐initiating capacity? What are cancer stem cells (CSCs)? They are cancer cells that have similar characteristics as normal stem cells. CSCs have the potential to give rise to other cells types, and thus are tumorigenic in nature. These cells can generate tumors via stem cell processes of self-renewal, as well as differentiation into different cells (Wang, Chiou & Wu, 2013). CSCs have been found to persist in tumors in the form of a district population and often cause relapse and metastasis ...
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