Drugs can have many differing affects on people, whether their consumption leads to a positive or adverse response. All of this depends on the levels of enzymes in the body and how the variations of expression lead to these possible outcomes. The major theme of the two sources on this topic relate to the specific enzyme, CYP3A. CYP3A is a subfamily of cytochrome P450 enzymes, which serve to catalyze the addition of oxygen into molecules. Their ultimate role serves two spectrums: to convert foreign substances into less toxic products that can be eliminated from the body, or to convert ...
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1. Introduction Opioids such as codeine and morphine, are the active pharmaceutical ingredients of many drugs such as pain relievers (analgesics), cough suppressants, sedatives, etc. Opioids are derivatives of opium and bind to the μ-opioid receptor (μOR). The coupling of the μOR to Gi, the inhibitory subunit of the G-protein, blocks the activation of adenylyl cyclase and results in the analgesic effect. The opioid receptors belong to the G protein-coupled receptors (GPCRs) superfamily and specifically to the rhodopsin-like family A. These receptors consist of two closely related members, namely, δOR and κOR (Manglik et al. 2012, p. 322). ...
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