BBB functions and physiology: The central nervous system (CNS) necessitates a highly controlled environment for its proper functioning. Blood brain barrier is the system which maintains the homeostasis of the CNS. It works by separating and shielding the brain from the constant changes in the nutrient and chemical composition of systemic blood. It protects the brain tissue from harmful chemicals that might be present in the blood. The key functions of the BBB are transport of nutrients from the blood to brain and metabolites in opposite direction to systemic circulation. Only a small number of molecules are allowed access through the ...
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