Hypertension is one of the chronic illnesses whose presence within the communities in the last one decade has been significantly felt. The morbidities, mortalities and costs incurred in management and treatment are issues that have impacted on individuals, families and communities (Ferdinand, 2013). Within the US, there are significant disparities especially from a racial perspective in the cases of hypertension. As at present, it is estimated that 41% of African Americans have hypertension which is a high figure as compared to the 27% of Whites who have hypertension (Flack, Nasser & Levy, 2011). Further, up to 28% of African Americans ...
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Diuretics targets to lower sodium and water reabsorption that may lead to enhanced water excretion. The main aim of diuretics is to reduce the fluid volume inside the body and maintain the electrolyte and water equilibrium. These agents are used for managing the pathological conditions including hypertension and edema such as cardiac congestion failure, liver and kidney problems, and glaucoma. It also helps in processing and regulating the blood pressure by eliminating the excessive salt from the body which slows down the cardiac muscles to impel the ...
Assignment 2
PART A - (Total 15 marks)
Cephalexin and Gentamicin The mechanism of action of amoxicillin is focused on the prevention of the synthesis of the bacteria’s cell wall through the binding and inhibiting of the cell wall transpeptidases (Katzung, Masters, and Trevor, 2012). Specifically, it attaches to the penicillin-binding protein 1A found in the cell wall of bacteria. Then, the agent disintegrates the lactam ring to allow the acylation of the penicillin-sensitive transpeptidase C-terminal domain. The formation of the cross-link of the linear peptidoglycan strands is prevented by the inactivation of transpeptidases. Since the third and last stage ...
In Wright et al.'s "Systematic Review of Antihypertensive therapies: Does the evidence assist in choosing a first-line drug?" the researchers review 38 different trials in order to determine if a first-line drug is identified in the realm of antihypertension drugs. According to the Critical Appraisal Skills Programme (CASP) appraisal tool, the researchers provide a valid study that can provide clear policy and practice change in the field of hypertension research and treatment.
The researchers, in their review, ask a clearly focused question - they wish to compare the effectiveness and efficacy from reputable trials in order to find first-line drugs for antihypertension therapies, ...