The single-celled parasite, Plasmodium falciparum, causes malaria, was responsible for 214 million cases and 438,000 deaths globally in 2015, of which 88% of cases and 90% of deaths occurred in sub-Saharan Africa. The morphology of P. falciparum is characterized by numerous rings (young trophozoites) and the absence of mature trophozoites and schizonts. In a P. falciparum blood smear, multiple infected erythrocytes appear more often than in other species and the rings of the parasite in the blood smear tend to be smaller than other species. Distinctive crescent-shaped gametocytes appear late in the infection. In vitro cultivation of P. ...
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1. When I was at the high school, many professors said to me the importance to acquire managerial skills to grow in organizations and to have financial skills to have control of my finances. I did not have the intention to abandon my career because I love the idea to design and develop new products, but I knew that a 9-to-5 job does not have the possibilities to convert me into a rich person, but at least I wanted to develop the financial skills. In 2005, when I finished the high school, I started to work in a restaurant ...
Abstract
Plasmodium falciparum is the parasite responsible for the deadly disease, malaria. The parasite is transmitted through the injection of sporozoites into the human blood stream. These sporozoites are transported in the blood stream to the liver. The sporozoites invade the hepatocytes and differentiate into merozoites. The merozoites invade the RBCs of the host; starting the blood stage of infection. The trophozoite stage ingests and degrades approximately 80% of the hemoglobin in the host cell. The hemoglobin is broken down into peptides due to enzymatic action by a metalloprotease and cysteine and aspartic proteases. Haematin is first released as a byproduct of ...